Protein Details: Neuronal acetylcholine receptor subunit beta-4

Protein ID

ICDB_Pro_0440

Protein Name

Neuronal acetylcholine receptor subunit beta-4

Gene Name

CHRNB4

Organism

Gallus gallus (Chicken)

Length

470 amino acids

AlphaFoldDB

AF-P26153-F1-model_v4.pdb

Function

After binding acetylcholine; the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Sequence

STAADAEEKLMNHLLSPDRYNKLIRPAVNSSQLVSIELQVSLAQLISVNEREQIMTTNVWLNQEWIDYRLAWKPSDYEGINMLRIPAKHIWLPDIVLYNNADGTYEVSLYTNAIVQNNGSIRWLPPAIYKSACKIEVKHFPFDQQNCTLKFRSWTYDHTEIDMVLKTSMASMDDFTPSGEWDIVALPGRRTENPLDPNYVDVTYDFIIKRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHTMPPWVKLVFLERLPAYLFMKRPENNSPRQKPANCKKTRAENLCMDPADFYKNSTYFVNTASAKKYDMKITDTLDNVSSHQDFRLRTGTKFSPEVQEAIDGVSFIAEHMKSDDNDQSVIEDWKYVAMVVDRLFLWIFVLVCVLGTVGLFLQPLFQNHIAATNP

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

SITE 54: "Key residue that may interfere with effective access of the conotoxin BuIA to the channel binding site"; SITE 106: "Key residue for a rapid dissociation (K(off)) from the conotoxin BuIA"; SITE 114: "Key residue for a rapid dissociation (K(off)) from the conotoxin BuIA"

Disease

Location

DOI ID

10.1093/nar/18.17.5307